I saw a GP about it (not my usual one) and they strongly suspect it is being caused by MTX but I have just spoken to the Rheumy nurse who thinks Hydroxy is the more likely suspect or it may be an autoimmune response so now I have to withhold all rheumy meds. It seems to improve when I am on steroids but only at higher doses. Thanks, Tamara I am on all sorts of meds including MTX and Hydroxy. Chloroquine primaquine babesia forum Chloroquine cytokine Skin rash; Serious Side Effects of Plaquenil. You can browse Drugs A-Z for a specific prescription or over-the-counter drug or look up drugs based on your specific condition. This information. Hydroxychloroquine is a DMARD. The brand name is Plaquenil. What does Plaquenil do? Plaquenil relieves pain and swelling and prevents damage to joints. How long does Plaquenil take to work? Plaquenil works very slowly. In 1 to 3 months you should start to feel better. You may continue to get better for up to 1 year. I broke out with a rash after being on it for a week. I was also on a mild muscle relaxer for about 3 weeks prior to plaquenil. I got off both then started back on plaquenil. No rash so I assumed it was the other med even though I was on it longer and before the plaquenil. Did not resume the other meds. I can't face the GP again, as I am sure I am one of the "heart-sink" patients! I have recently developed an itchy rash which only affects my cheeks and eyebrows and haven't a clue what's causing it, so I hope you get some helpful replies that might help me too! What does a plaquenil rash look like Plaquenil --rash., Lupus Medicines Hydroxychloroquine - Brigham and Women's. Plaquenil swellingWhat does hydroxychloroquine do to your eyesIs there a generic drug for plaquenil How does Plaquenil work? Surprisingly, the reason for its success in lupus still remains somewhat mysterious. It has a wide variety of known effects – aspirin-like anti-inflammatory, mild immunosuppressive and mild cholesterol lowering amongst others. Perhaps an important property is that of sun-protection. Plaqunil rash -. Plaquenil rash I just started taking. - Sticky Blood.. Immune & Autoimmune - Lupus Anyone Get An Itchy Rash From. I've been on Plaquenil for 6 weeks. I developed a red, raised, welt rash that looked like zebra stripes after being in the sun for 10 minutes. It went away within 30 minutes but then my joints all flared up the next few days. Check with your doctor! SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Side effects include irritability, headache, weakness, hair lightening or loss, stomach upset, nausea, dizziness, muscle pain, rash and itching. Rarely, hydroxychloroquine can affect the bone marrow leading to reduced white blood cells leukopenia or platelets thrombocytopenia and abnormal red blood cells but potentially serious eye toxicity can occur.