There’s no cure for arthritis, which is unfortunate, but feeling better is definitely possible. The progression of RA may be diminished in severity and duration by the combination of medicines and therapy that work best as determined by you and your physician. Chloroquine po 300 mg daily prophylaxis Hydroxychloroquine lupus erythematosus Although Plaquenil is an older drug, it is still available and prescribed to some people who have rheumatoid arthritis or certain other rheumatic diseases. Plaquenil is a DMARD which has been prescribed for years to treat rheumatoid arthritis, lupus, juvenile rheumatoid arthritis, and other autoimmune diseases. Depending on how full your stomach it codine should take 20 min to a hour to work. Last week my doc added plaquenil to the mix. I have a pharmacist friend that says it can take up to a year to work, but once its kicks in it can be really good. I suggest you ask your rhuemie for additional help in the meantime. I have had RA going on 12 years, and originally way back when I ws given plaquenil alone and it did nothing. Being able to stop joint damage can lessen pain and mean a better quality of life. You can also put off joint damage, and in some cases, you can do more than just slow it down. When does plaquenil start working RA and Hydroxychloroquine How Effective is it for., How long does it take for plaquenil to work - Answers Mylan pharmaceuticals hydroxychloroquineDoes hydroxychloroquine have renal toxicityPlaquenil coupon card Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. Hydroxychloroquine - Wikipedia. How long did Plaquenil/Hydroxychloroquine take.. Plaquenil User Reviews for Rheumatoid Arthritis at. Hydroxychloroquine is a one of a number of drugs which have been used for many years in the treatment of malaria. Fortunately, it was discovered these drugs often are helpful in the treatment of various rheumatic diseases, particularly systemic lupus erythematosus SLE or "Lupus" and rheumatoid arthritis. Plaquenil for fatigue and pain. My dr said the Plaquenil takes long time to start working, but for some people, like me, it has a great long term benefit. I started Plaquenil 2 months ago. My Rheumatologist told it can up to 3 months to start working. Be very careful with plaqenil. Yes, it was great for the pain but I bloated up and put on a great deal of weight very quickly.