Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Can plaquenil cause extreme fatigue Novo-chloroquine 250 mg side effects How much is plaquenil without insurance Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Hydroxychloroquine is a DMARD. The brand name is Plaquenil. What does Plaquenil do? Plaquenil relieves pain and swelling and prevents damage to joints. How long does Plaquenil take to work? Plaquenil works very slowly. In 1 to 3 months you should start to feel better. You may continue to get better for up to 1 year. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Do joints hurt more when starting plaquenil Hydroxychloroquine Side Effects, Dosage, Uses, and More, Hydroxychloroquine Plaquenil How does plaquenil help fight lupusPlaquenil loss of appetiteLupus medicines hydroxychloroquine brighamGougerot sjogren traitement plaquenil With age, stiff joints become a reality for many people. Years of use can take their toll on joints, muscles, and bones. Many people experience stiff joints just after waking up. Stiff Joints Why They Hurt and How to Treat Them. Lupus Medicines Hydroxychloroquine - Brigham and Women's.. Can stopping Plaquenil cause joint pain to return?. I've been taking plaquenil for about 5 years now. I gain weight with it. I take daypro for my RA also. I think the daypro helps with the swelling, as far as the pain goes there is always pain, in time you just learn to ignor and grow a higher tolerance for pain. I've had RA for 18 years. I'm 40 now. I was 22 when I found out I had RA. But eventually I couldn't do it any longer. And yes, it certainly helped me with overall pain. I do still have pain though. Regular eye tests are recommended once you start it, and I've recently had one. So far, I have no eye issues that could be attributed to plaquenil. I still have bad fatigue. Plaquenil is NOT known to start working that fast. It takes anywhere from 4-6 months before the affects of Plaquenil are seen/felt. Now, I'm in week six and I again have the joint pain, joint stiffness and fatigue. Plaquenil - Can It Work Quickly? I tried to get on Plaquenil years ago, and couldn't tolerate it, but now I'm thinking.