One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Plaquenil depletes magnesium Germany plaquenil Plaquenil time of onset Retinal drusen form as an accumulation and aggregation of lipofuscin waste products of the RPE and photoreceptors at the layer of Bruch‟s membrane. Drusen are most commonly seen in atrophic retinal disease such as age-related macular degeneration, although they may be seen in relatively benign conditions such as dominant familial drusen. Drusen. The appearance of drusen — yellow deposits — in the retina indicates the development of early-stage dry macular degeneration left. As the condition progresses to the advanced stage right, the drusen get larger, bleeding occurs and the light-sensitive cells that make up the macula become scarred. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Drusen plaquenil Autofluorescence of Basal Laminar Drusen, Dry macular degeneration - Diagnosis and treatment - Mayo. Can plaquenil grow hairCan plaquenil help age the skin fasterColchine as a trail vs plaquenil Basal Laminar Drusen. Basal laminar drusen is a condition in which yellow round deposits of lipid waste accumulate between the base of the retinal pigment epithelium and Bruch's membrane in the outer retina. These lesions appear in young adulthood as opposed to the drusen of age related macular degeneration which develop in late life. Basal Laminar Drusen - The Retina Reference. Hydroxychloroquine-Induced Retinal Toxicity - American.. Subretinal Drusenoid Deposits vs. Drusen - OCTMD. Dr. Marmor’s research team also recommended that screening should be performed within the first year of initiating therapy, and then annually after five years of Plaquenil use. The risk for retinal toxicity begins once the patient has used Plaquenil for five to seven years and/or has taken a cumulative dose of more than 1,000g. Drusen are small yellow deposits of fatty proteins lipids that accumulate under the retina. The retina is a thin layer of tissue that lines the back of the inside of the eye, near the optic nerve. Des, I am sorry to here that the plaquenil maybe causing you same trouble with your eyes. If the plaquenil is the issue maybe you can try half of what you need. The one thing good is that your eyes will clear up if it is the plaguenil, the down side is you will have to find something else. Best to you.