Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Retinal pigment epithelial mottling of macula plaquenil Plaquenil and radiation therapy toxiciy Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. When my wife was first diagnosed with PMR in May, 2016, she was put on 15mg Pred. A month later, she was told to take 400mg of plaquenil daily, with the understanding that plaquenil would replace prednisone eventually. This rheumy tried to get her down to 5mg six months later, which was a total mistake. More in Eye Health. If you are taking Plaquenil to treat an inflammatory condition or malaria, you should be aware of the side effects that may occur to your eyes and vision. Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Plaquenil and prednisone interaction Prednisone and Plaquenil question" Lupus Community., Plaquenil? I have been on prednisone for 15 months. - PMRGCAuk What is hydroxychloroquine is forDoes plaquenil contain sulfate Side effects of prednisone that are different from Plaquenil include acne, thinning skin, weight gain, restlessness, and trouble sleeping. Both Plaquenil and prednisone may interact with antibiotics, tuberculosis medications, nonsteroidal anti- inflammatory drugs NSAIDs, HIV / AIDS medications, estrogens including oral contraceptives or hormone replacement therapy, or seizure medications. Plaquenil vs. Prednisone Prescription Treatment for Rheumatoid.. Plaquenil Side Effects on Your Eyes and Vision. Does Plaquenil interact with Prednisone?. By Connie Rifenburg June 3, 2015 at pm. Ang, I had hair loss pretty severe when I first started on Prednisone, Plaquenil, and Methotrexate. I guess it may depend on the dosage, and hopefully your hair loss will stop as mine did after a few months. If common side effects do occur, they are usually minor and last only for a short period of time. Please note the rare side effects listed below, specifically retinopathy, which causes damage to the eyes. Side effects associated with Plaquenil are placed in three categories common, less common, and rare. Rheumatoid arthritis is a chronic disorder for which there is no known cure. Fortunately in the last few years, a shift in strategy toward the earlier institution of disease modifying drugs and the availability of new classes of medications have greatly improved the outcomes that can be expected by most patients.