Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Chloroquine phosphate testing kit Chloroquine plus primaquine Chloroquine elimination route Taking plaquenil FUNDUS AUTOFLUORESCENCE FINDINGS IN EARLY CHLOROQUINE MACULOPATHY. Background/Purpose Toxic maculopathy is a rare but severe complication of chloroquine intake. Although the phenotype of established maculopathy was analyzed in detail, few data exist on the ophthalmologic findings in the early stage. Today it is recommended that every single person on Plaquenil get a visual field 10-2 test, plus one of the three other highly sensitive screening tests the FAF fundus autofluorescence imaging, the SD-OCT spectral domain optical coherence, or the multifocal electroretinogram mfERG,” Thomas says. Problems with Plaquenil Use Toxic maculopathy associated with chloroquine use was first documented in the literature five decades ago.1 In the United States, Plaquenil––an analog to chloroquine––is used to treat a variety of conditions, including rheumatoid arthritis, lupus and several distinct inflammatory disorders. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Plaquenil maculopathy autofluorescence Retinal Physician - Hydroxychloroquine Maculopathy An., Protecting your eyesight when taking Plaquenil Lupus. What is chloroquine aralenPlaquenil pain relief Ultra-widefield fundus autofluorescence images placed in order of severity in the eyes with hydroxychloroquine retinopathy with a parafoveal dominance pattern. Retinopathy varies from ring-shaped parafoveal hyperautofluorescence to round macular hypoautofluorescence and finally to bull's eye maculopathy with peripheral involvement rightmost. Evaluation of Hydroxychloroquine Retinopathy Using Ultra.. New Plaquenil Guidelines. Drug induced maculopathy - EyeWiki. Fundus Autofluorescence and Spectral Domain Optical Coherence Tomography in Early Detection of Plaquenil Maculopathy Amy T. Kelmenson, Vikram S. Brar, Ravi K. Murthy, and Kakarla V. Chalam, MD, PhD European Journal of Ophthalmology 2018 20 4, 785-788 Rheumatologists use hydroxychloroquine sulfate Plaquenil, Concordia Pharmaceuticals to treat autoimmune diseases, namely discoid or systemic lupus erythematosus, rheumatoid arthritis, Sjögren syndrome, and malaria. When taken at high doses and for long durations, hydroxychloroquine has been known to cause parafoveal retinal toxicity. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus.