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    One review found low-quality evidence that low-dose colchicine (1.8 mg in one hour or 1.2 mg per day) reduced gout symptoms and pain, whereas high-dose colchicine (4.8 mg over 6 hours) was effective against pain, but caused more severe side effects, such as diarrhea, nausea or vomiting. There is preliminary evidence that daily colchicine (0.6 mg twice daily) was effective as a long-term prophylaxis when used with allopurinol to reduce the risk of increased uric acid levels and acute gout flares, In gout, inflammation in joints results from the precipitation of circulating uric acid, exceeding its solubility in blood and depositing as crystals of monosodium urate in and around synovial fluid and soft tissues of joints. About 10-20 percent of a colchicine dose is excreted unchanged by the kidneys; it is not removed by hemodialysis. Cumulative toxicity is a high probability in this clinical setting, and a severe neuromyopathy may result. The presentation includes a progressive onset of proximal weakness, elevated creatine kinase, and sensorimotor polyneuropathy. Colchicine toxicity can be potentiated by the concomitant use of cholesterol-lowering drugs. According to one review, colchicine poisoning by overdose (range of acute doses of 7 to 26 mg) occurs in three phases: 1) a gastrointestinal phase occurring 10–24 hours after ingestion; 2) a phase having poor prognosis involving multiple organ dysfunction occurring 24 hours to 7 days after ingestion, potentially evolving into rapid, progressive multi-organ failure and sepsis; 3) several weeks would be needed for a complete recovery if there are no complications. I use Viagra Super Force to treat my erectile dysfunction and I am quite successful at it. The thing is that my penis got considerably weaker during the last few years. At first I started with herbal meds and mild solutions, but they were ineffective and my erectile dysfunction was getting worse and worse. I was ashamed of my inability to maintain long-lasting erection and started avoiding sexual relations with my wife. It goes without saying that with time there occurred serious misunderstanding and quarrels between us. Then I went to my doctor and asked for a serious solution and he advised me to try Viagra. The result was much better than with all those herbal cocktails and teas but still not what I expected. So I started my web investigation and soon came to the conclusion that Viagra Super Force deserves my attention.

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