You’re probably here because you want to gain muscle or lose fat faster and you’re wondering if estrogen blockers can help. You’ve probably also seen fantastical claims about what these drugs and supplements can do to your physique. Thousands of others are searching about estrogen blockers every day, too, because they’ve heard the same blarney that brought you here. And in this article, we’re going to get to the bottom of it all. Now, the war against estrogen is at a fever pitch these days because it’s riding on the coattails of its big brother, testosterone, which is also on a lot people’s minds. It’s common knowledge that raising your testosterone levels can help you gain muscle and strength and lose fat faster, which is why more and more people are snapping up testosterone booster supplements and signing up for testosterone replacement therapy. Most people also know that raising testosterone levels also raises estrogen levels, and that high estrogen levels is generally associated with higher levels of body fat, erectile dysfunction, and feminizing effects like gynecomastia. Furthermore, it’s also often assumed that lowering estrogen levels in and of itself can improve body composition and virility, and especially in people that are “estrogen dominant” and thus incapable of gaining any considerable amount of muscle and strength. 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SERMs serve to block the action of Estrogen at the receptor sites in breast tissue by occupying the receptor sites in place of Estrogen so that Estrogen itself cannot exert its effects there through receptor site binding. Conversely, SERMs will also act as Estrogens at receptor sites at other cells in other areas of the body (the liver, for example in Nolvadex’s case). Generic name: Tamoxifen uses generic names in all descriptions of drugs. In some cases, health care professionals may use the trade name Nolvadex when referring to the generic drug name Tamoxifen. This medication is classified as an "anti-estrogen." (For more detail, see "How this drug works" section below). side effect of tamoxifen is blood clots, including deep vein thrombosis (DVT) and pulmonary embolus. You should seek emergency help and notify your health care provider immediately if you develop sudden chest pain and shortness of breath. 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