One of the downfalls to the wildly increasing popularity of CBD use is that not a lot of research has been done in regard to its potential interaction with other drugs. Like any drug, CBD is a chemical compound that has specific effects on various pathways in the body. Thus, it’s important to understand whether or not these effects may be dangerous or counterproductive when taken along with other substances. Fortunately, it’s becoming more and more widely accepted that CBD is generally safe to use, even when taken along with other meds. Department of Health issued a statement several years ago claiming that “serious adverse [side] effects are rare with [the use of] cannabis or its constituents.”That being said, a few studies have shown that in significant enough doses, CBD can inhibit or deactivate a class of liver enzymes that are important for the efficient metabolization (breakdown) of prescription medications. An updated published earlier this summer (2017) confirmed the “favorable safety profile” of CBD in humans, and in fact showed that it had a better side effect profile when compared to other medications with similar functions. Accumulation of unmetabolized drugs can potentially be dangerous in that it allows for the stagnant buildup of compounds in the liver, as well as a prolonged effect of the drug. In this article, we’ll go over some common medications that have been known to be affected by continuous, high-dosage CBD use, and also talk about prescriptions for common medical conditions that may pose potentially adverse interactions with the natural cannabinoids like CBD. First, though, it’s important to understand that this is by NO MEANS a comprehensive guide on which drugs are safe to take with CBD, and which are not. tamoxifen after mastectomy Hello, I had a severe allergic reaction two weeks ago to an unknown substance, and they gave me prednisone thru IV at the ER. Then they sent me home with a 15 day taper of tablets...60mg for 5 days, 40mg for 5 days, and finally 20 mg for 5 days. more »Hello, I had a severe allergic reaction two weeks ago to an unknown substance, and they gave me prednisone thru IV at the ER. Then they sent me home with a 15 day taper of tablets...60mg for 5 days, 40mg for 5 days, and finally 20 mg for 5 days. They did not tell me ANYTHING about this drug, and had I known the awful way it would make me feel, I would have refused it. Throughout the time I was taking the pills, I had terrible anxiety (which, I usually have anxiety, but nothing as intense as this), crying spells, heart palpitations, trouble breathing, you name it! I spoke to my doc and some pharmacists who told me that these were all side effects of the prednisone and should subside once the drug is out of my system. Well, I took my last 20mg Friday morning (Aug 1), and have not felt much better since then. 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