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    In the Scandinavian Simvastatin Survival Study (a placebo-controlled, randomized clinical trial of five years' duration), simvastatin reduced overall mortality in people with existing cardiovascular disease and high LDL cholesterol by 30% and reduced cardiovascular mortality by 42%. The risks of heart attack, stroke, or needing a coronary revascularization procedure were reduced by 37%, 28%, and 37%, respectively. The Heart Protection Study evaluated the effects of simvastatin in people with risk factors including existing cardiovascular disease, diabetes, or stroke, but having relatively low LDL cholesterol. In this trial, which lasted 5.4 years, overall mortality was reduced by 13% and cardiovascular mortality was reduced by 18%. People receiving simvastatin experienced 38% fewer nonfatal heart attacks and 25% fewer strokes. Results from one trial showed participants assigned to simvastatin had lower odds (0.51 OR) of having AMD progression at three years compared to those assigned to placebo, though the results were not significant. A type of DNA variant known as a single nucleotide polymorphism (SNP) may help predict individuals prone to developing myopathy when taking simvastatin; a study ultimately including 32,000 patients concluded the carriers of one or two risk alleles of a particular SNP, rs4149056, On March 19, 2010, the FDA issued another statement regarding simvastatin, saying it increases the risk of muscle injury (myopathy) when taken at high doses or at lower doses in combination with other drugs. can you buy viagra on amazon Simvastatin is used together with diet, weight-loss, and exercise to reduce the risk of heart attack and stroke and to decrease the chance that heart surgery will be needed in people who have heart disease or who are at risk of developing heart disease. Simvastatin is also used to decrease the amount of fatty substances such as low-density lipoprotein (LDL) cholesterol (''bad cholesterol'') and triglycerides in the blood and to increase the amount of high-density lipoprotein (HDL) cholesterol (''good cholesterol'') in the blood. Simvastatin may also be used to decrease the amount of cholesterol and other fatty substances in the blood in children and teenagers 10 to 17 years of age who have familial heterozygous hypercholesterolemia (an inherited condition in which cholesterol cannot be removed from the body normally). Simvastatin is in a class of medications called HMG-Co A reductase inhibitors (statins). It works by slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body. Take simvastatin at around the same time every day. Accumulation of cholesterol and fats along the walls of your arteries (a process known as atherosclerosis) decreases blood flow and, therefore, the oxygen supply to your heart, brain, and other parts of your body. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Do not take more or less of it or take it more often than prescribed by your doctor. Lowering your blood level of cholesterol and fats with simvastatin has been shown to prevent heart disease, angina (chest pain), strokes, and heart attacks. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information. Your doctor may start you on a low dose of simvastatin and gradually increase your dose, not more than once every 4 weeks.

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    In a study comparing LIVALO and Zocor® simvastatin, LIVALO 2 mg was shown to. Zocor® simvastatin can interact with other drugs you may be taking. azithromycin for pertussis Dec 16, 2014. Simvastatin is a medication included in the class of drugs called statins. Statin drugs are used together with diet and exercise to reduce blood. Zocor simvastatin belongs to a group of drugs called HMG CoA reductase inhibitors, or "statins." Simvastatin reduces levels of "bad" cholesterol low-density lipoprotein, or LDL and triglycerides in the blood, while increasing levels of "good" cholesterol high-density lipoprotein, or HDL.

    The treatment of high cholesterol has improved care for many people. Most people who have diabetes or those who have had a stroke or heart attack benefit from lower cholesterol levels. Medications called “statins” are the most commonly prescribed drugs used to reduce cholesterol. Some examples of statin medications are Lipitor® (atorvastatin), Pravachol® (pravastatin), Zocor® (simvastatin), Livalo® (pitavastatin) and Crestor® (rosuvastatin). Unfortunately, some people may experience muscle pain or weakness while taking statins. The pain may be minor such as soreness or stiffness. However, muscle pain, particularly if severe and accompanied by dark-colored urine, may be an indication of a more serious, life-threatening problem called rhabdomyolysis. The information you provide may be used to send you health-related materials and to develop products, services, and programs. We may also contact you to participate in market research. Astra Zeneca, or third parties working on our behalf, will not sell or rent personal health information. In the future, if you no longer want to receive health-related materials or wish to be contacted, call The information you provide may be used to send you health-related materials and to develop products, services, and programs. We may also contact you to participate in market research. Astra Zeneca, or third parties working on our behalf, will not sell or rent personal health information.

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    Some studies have reported that as many as 85% of people with diabetes experience fatigue, defined as excessive tiredness that interferes with one or more life functions. See a couple of articles on getting better sleep here and here. That’s why many cultures encourage a siesta (rest) in those hours. Can you think of one person or creature who makes you feel better? Let’s focus on quality of life over quantity of stuff done or acquired. As a Diabetes Self-Management reader named Donnah wrote, “Since being diagnosed with Type 2 diabetes, my housework suffers dramatically, I don’t do half of the things that I used to do with my child. Most jobs frown on napping, but if you can find a way, embrace your nap. Do what you can to bring your sugar down, whether it’s diet, exercise, supplements, or medicines. If you can’t get sunshine, maybe buy a full-spectrum light that mimics the sun’s effects. • Find something you love and apply yourself to it. Find your personal balance between work, play, improvement, service, and rest. When I do find the time and energy to do things, I am easily worn out and need to rest. I am on disability because of it and I hate this.” Causes of fatigue How does diabetes make you tired? The same thing happens with poorly controlled diabetes. If there’s no reason to get up, your body won’t want to. • Get tested for anemia, thyroid, and other possible causes of your fatigue. Compact fluorescent lights (CFLs) marked “cool white” or “daylight” are also better than standard incandescent bulbs. Try to stop what you’re doing every couple of minutes and focus on your breathing for a minute. You might even find something to do on the Internet. • High blood sugar makes blood sticky, so it can’t get through the capillaries as easily to bring oxygen to cells. High blood sugar can mean having that feeling all the time. • Hypoglycemia, or low blood sugar, can cause fatigue. • Ask a pharmacist if your medications could be causing fatigue. A reader named Kat commented that since she started “juicing green leafy vegetables in the morning, with some wheatgrass…and eating a higher-protein and -fat, lower-carbohydrate diet, I have shaken off…the extreme fatigue that I used to have every day.” • Supplements. • Do some kind of gentle movement like walking or tai chi. My blog The Inn by the Healing Path is full of stories of people healing by committing to what they love. • Insulin resistance keeps glucose out of body cells, so they don’t have fuel. • The mental stress of coping with diabetes can wear out your mind and spirit. Changing hours of sleep and activity confuses your body, and it may be difficult to get the sleep you need. Ginseng, vitamin B12, magnesium, alpha-lipoic acid, acetyl-L-carnitine, and coenzyme Q-10 are recommended by several authorities. Many other conditions besides diabetes can cause fatigue. If your sugars are under control, but you still lack energy, consider being tested for: • Sleep apnea, which causes exhaustion and is very common in diabetes. Metformin Side Effects - Healthline buy tadacip uk Does Metformin Cause You Any Fatigue? - Diabetes Daily Metformin Oral Route Precautions - Mayo Clinic
     
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