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Orlistat, which is available locally under different brand names, is the only anti-obesity drug approved for over-the-counter sale. When a drug is approved as such, that means there’s no significant risk for people to take it even without a doctor’s prescription. For those who have taken the product, they know that it is a potent inhibitor of the absorption of dietary fats in the intestines. Hence, one needs to go to the bathroom shortly after eating a fatty meal because the fat goes down the gut with reduced absorption and has to be passed out. reported in 2006 that in preclinical studies using experimental rats, orlistat was associated with increased numbers of cells believed to be potential precursors of colon cancer. Therefore, common side effects experienced by those who take it include oily stools, fecal spotting, diarrhea and abdominal pain. They called these cells as “aberrant cryptic foci.” The experts were divided whether or not these are real precursors of colon cancer. 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